Last week, Wenger explained the importance of Cazorla - who has become Arsenal's first-choice central midfielder after joining the club as an attacking midfielder or winger - to the way his side functions.
"Santi is important to our technical stability in the team, to the quality of our decision-making and to our build-up from deep midfield to the high midfield," the Frenchman told reporters.
Could Ronaldinho join Chapecoense?
"That is an important stage because it gets the ball out from the defenders. Santi is a massive player for us.
"But we have enough quality players in our side to get around that. We are good enough to find solutions despite the fact he is not there."